TMPRSS3 Hearing Loss Resource

Welcome

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TMPRSS3.org was created by a Girl Scout, with guidance from some of the world’s greatest scientists, to help people understand TMPRSS3 genetic hearing loss, connect with research, and find reliable information about genetic testing, cochlear implants, gene therapy progress, and current studies.

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TMPRSS3-related hearing loss is usually inherited in an autosomal recessive pattern, meaning a person typically has two variants in the TMPRSS3 gene. It can cause congenital severe-to-profound hearing loss, later-onset progressive hearing loss, or high-frequency hearing loss that changes over time.​​

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For families newly diagnosed

Learn what TMPRSS3 is, how it affects hearing, what genetic test results may mean, and what questions to ask.

• TMPRSS3 Hearing Loss

• Genetic Testing

• Gene Therapy

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For those with progressive hearing loss​

TMPRSS3 can be associated with progressive hearing loss, including cases in which cochlear implants may become an important option. Consider participating in research to help advance the field.

• TMPRSS3 Hearing Loss

• Researchers

• Gene Therapy​

• Participate in Research

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For medical providers/researchers

Find over 100 studies, leading researchers, genetic testing resources, and current information about TMPRSS3-related hearing loss, cochlear implantation, and emerging treatment research.

• Research

• Researchers

• Genetic Testing

• Gene Therapy