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Participate in TMPRSS3 Research 

Get involved with Transmembrane Serine Protease 3/ TMPRSS3 hearing loss research.
If you know of more research studies, submit them below.


Turn your own skin cells into stem cells. If you have a confirmed diagnosis of TMPRSS3-related hearing loss, Dr. Rick Nelson has developed a process of taking human tissue and turning it into stem cells. These stem cells can be used to make "inner ear organoids", which have sensory cells similar to the human cochlea. These organoids can help understand how  the gene causes hearing loss. His lab is currently doing similar research with mice that also have a mutation.


This research would require an in-person visit to the University of Indiana and/or a blood draw.

NIH Research Grant


Contact Dr Rick Nelson, Associate Professor of Otolaryngology-Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, IN.   Email for more information. 

If there are any TMPRSS3 clinical trials, they will be listed at

Scientist using DNA Chips

 Crowd-Source TMPRSS3
Hearing Loss

Do you have a confirmed diagnosis of hereditary hearing loss due to pathogenic variants in the TMPRSS3 gene? Send us a note.


With your help and connection we can keep developing resources to help understand and potentially treat DFNB8/10 hearing loss. 

New gene therapies and precision medicine approaches to hearing loss are in the works. With better  diagnostics and a potential genetic newborn hearing screening, this field is changing rapidly. 

When we discover exciting new research and possibilities, we'll post it here.

Email us at


Sending TMPRSS3 Hearing Loss Audiograms
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