TMPRSS3 Hearing Loss Research
The latest TMPRSS3 research updates, a searchable database, and a visual summary of TMPRSS3 hearing loss research from 1996 to 2026. This page tracks published studies, research trends, clinical findings, and gaps in TMPRSS3-related hearing loss research.
Latest TMPRSS3 Research Updates
TMPRSS3 research is moving quickly. Here are some of the most important recent updates for families, clinicians, and researchers.
A 2026 study found new TMPRSS3 gene changes, including splice-site variants that can interfere with how the gene is read. These changes caused parts of the gene message to be skipped and appeared to reduce TMPRSS3 enzyme activity more strongly than some other types of variants. This gives researchers another clue about why TMPRSS3-related hearing loss can be mild, severe, early-onset, later-onset, or progressive depending on the person’s specific variants.
Research on why TMPRSS3 hearing loss may occur
A 2025 mouse study gave researchers a new clue about why hair cells may die in TMPRSS3-related hearing loss. The study found that the cochlea’s normal electrical force, called endocochlear potential, may become harmful in a TMPRSS3 mouse model. When researchers lowered this electrical force, including with furosemide, fewer hair cells died. This is early research in mice, not a treatment for people yet, but it may help guide future therapies.
Natural history study helps define TMPRSS3 hearing loss
A 2024 natural history study analyzed TMPRSS3-related hearing loss, genotype-phenotype patterns, progression, hearing technology use, and cochlear implant outcomes. This type of research is important for genetic counseling, clinical care, and future clinical trials.
TMPRSS3 Gene - Hearing Loss Research Database
Below is a database of research studies related to or on Transmembrane Serine Protease 3 (TMPRSS3) hereditary hearing loss from 1996 to 2026 (updated March 2026). The database includes titles of the research, abstracts, authors, links to the articles, dates published, categorizations used for the research below, and more. If you want to search on your own for TMPRSS3 and congenital hearing loss research, try PubMed. You can also see the NIH TMPRSS3 Summary.
This OMIM sort of the existing research can also help guide you in specific areas like Cloning and Expression, Gene Structure, Mapping, Molecular Genetics, Animal Model, and seven specific Allelic Variants.
With 130+ studies on TMPRSS3, we wanted to understand what the research looked like. Through the following analysis, completed in 2022, we created multiple comparisons and graphs to observe changes over time and within different categories. These graphs show different things, such as where the research is headed, what has already been done, and, hopefully, gaps or new areas of study within this field.
Historical Analysis
Research Over The Years
Research has increased over the years, but recently declined. We analyzed how many research studies per year there have been on TMPRSS3-related hearing loss and on broader studies that mention TMPRSS3. (As of 9-5-26)
Research Trends (Every 5 years)
We categorized each study with the following labels: General Hearing Loss Gene Variant, TMPRSS3 Hearing Loss Variant, and Cochlear Implant Clinical Outcome Studies. We identified where they overlap and compared the categories to each other across the year spans. (As of 9-5-26)
Global TMPRSS3 Reach
This graph highlights the global reach of TMPRSS3 hearing loss. Studies were identified that analyzed country-specific populations. Certain populations may be within a genetic testing database that was studied in a different country. (As of 9-5-26)
