Hearing Loss Gene Therapy News (TMPRSS3 DFNB8/10)

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Plasmid and AAV Manufacturing Partnership to Advance Myrtelle’s Novel Gene Therapy for Monogenic Hearing Loss for Phase 1/2 Clinical Trials (DFNB8) (10/3/22)

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Myrtelle Enters into a Worldwide Exclusive License Agreement with Rescue Hearing to Develop and Commercialize Gene Therapy for the Treatment of Hearing Loss (DFNB8) (05/22/22)

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Rescue of Auditory Function by a Single Administration of AAV- TMPRSS3 Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8 (2/26/23)

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The Natural History of TMPRSS3-related Hearing Loss - (5/1/24)

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IU study finds possible treatment route for common type of genetic hearing loss - (9/10/25)

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Hearing Loss Gene Therapy News (Not TMPRSS3)

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Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Individuals With Congenital Deafness (Otof Gene Therapy) - (9-/1/25)

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Hearing Loss Gene Therapy Companies/Organizations

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In the future, gene therapy will be an option for people. We are tracking the latest companies, organizations, and news about gene therapy. Gene therapy could potentially restore, improve, and preserve hearing in individuals. There are currently no TMPRSS3 clinical trials for gene therapy; however, this may change soon.

 

Acousia Therapeutics - Committed to identifying and developing novel compounds (small molecules) to preserve and enhance natural hearing for patients suffering from sensorineural hearing loss.

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​Akouos - Advancing Precision Genetic Medicines with the Potential to Restore, Improve, and Preserve Hearing. Owned by Eli Lilly. Testing (and possibly free testing) Resources.

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Decibel Therapeutics - Exclusively focused on discovering and developing transformative treatments to restore and improve hearing and balance. Owned by Regeneron.

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Frequency - A clinical-stage biotechnology company focused on restoring function by developing therapeutics that activate a person’s innate regenerative potential.

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Myrtelle - A gene therapy company whose mission is to transform the treatment of neurological diseases. Involved in DFNB8 research.

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Otovia Therapeutics - A biotech company in China focusing on innovative drugs for diseases related to inner ear hearing loss. 

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Regeneron - A biotechnology company that invents, develops, and commercializes life-transforming medicines for people with serious diseases. 

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Rescue Hearing - The RHI mission is to “Eliminate Hearing Loss as a Chronic Condition”. Involved in developing TMPRSS3 gene therapies.

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Salubritas Therapeutics - Developing treatments for hearing loss, including genome editing, inner ear regeneration, novel delivery, and gene therapy.

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Sensorian - Offers innovative therapeutic solutions that provide long-term improvements for people living with, or at risk of, inner ear disorders.

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Inner Ear Gene Therapy Program - This laboratory, formerly part of the NIDCD Otolaryngology Surgeon-Scientist Program (OSSP), is focused on developing gene therapy as a treatment option for hearing loss and dizziness. ​​​

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